Firstly, 4 – DMT and ACO. David Nichols proposed O-acetylpsilocin, a hallucinogenic substance made synthetically, as a possible psilocybin substitute for pharmacological research. They are both thought to be psilocin precursor medications.
Psychedelic tryptamine 4 – ACO – DMT is also known as O – Acetylpsilocin, 4 – Acetoxy – DMT, or Psilacetin. It is a lower homolog of 4 – AcO – DET and is the acetylate version of the psilocin alkaloid found in psilocybin-producing mushrooms. 4 AcO, 4 AcO MiPT, and 4 AcO, 4 AcO DiPT. David Nichols has proposed the substance as a possible psilocybin substitute for pharmacological research. It resembles psilocin structurally. The three substances can be regard to have an equal subjective effect profile, with psilocybin producing the same consequences. Buy 4-ACO-DMT online.
Then, 4 – ACO – DMT and several other esters of psilocin were originally patented on January 16, 1963 by Sandoz Ltd via Albert Hofmann & Franz Troxler. Despite this fact.4 – AcO – DMT remains a psychedelic with a limited history of use prior to its release as a grey area compound on the online research chemical market.
The partial agonistic activity of 4 – ACO – DMT at the 5 – HT2A receptor is thought to be the source of its psychedelic effects. However, the significance of these relationships. And it’s still unclear how they provide the psychedelic sensation.
4 — ACO — DMT
Also, inside of the body. But this hasn’t been formally verified. And is based on claims that the majority of users are unable to distinguish between these two substances when they are swallow to the point that they are frequently taken into consideration. In terms of their subjective results, they are identical to one another.
But there are. claims that the effects of psilocin’s acetylate and non-acetylate versions vary subjectively. While some users claim that it lasts slightly longer than psilocin, others claim that it lasts for a significantly longer time.
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Secondly, It is important to highlight the dose-dependent nature of the research chemical before I go into detail about the 4-AcO trip. Then, Lower doses feel more like a psilocybin experience, while higher doses start to resemble a DMT experience, according to the general consensus among message board users and the nine respondents to a survey I made on 4-AcO. Alternatively, in the words of Sarah*, a participant in my survey, “It was like mushrooms, DMT, and acid in one… Similar to an extended DMT trip, but with the mind-blowing experience of acid and the warm, loving feeling of mushrooms, shop here.
4-AcO Dose Ranges for Oral Ingestion:
- Microdose: 2.5 – 5 mg
- Low Dose: 5 – 10 mg
- Moderate Dose: 10 – 20 mg
- High Dose: 20 – 40 mg
- Heroic Dose: 40 mg +
Thirdly, Many claim that oral doses in the 15–20 mg range are very similar to the 3.5-gram magic mushroom experience. In order to gain a sense of the terrain before delving into more intense experiences, it’s advisable to begin using any new psychedelics with a low to moderate dosage, or even a microdose, on your first trip.
Also, Doses for nasal ingestion will differ slightly because many people report that snorting the powder produces a stronger, possibly quicker-acting effect. Don’t be alarmed if this also happens to you. Additionally, one of my survey respondents said the powder can turn blue in your nostrils.
4-AcO Dose Ranges for Intranasal Ingestion:
- Microdose: less than 5 mg
- Low Dose: 5 – 10 mg
- Moderate Dose: 10 – 20 mg
- High Dose: 20 – 30 mg
- Heroic Dose: 30 mg +
In addition, make sure to weigh your dosage on a milligram-readable scale for safe dosing. If you don’t already have one, you ought to think about investing. They are an inexpensive method of harm reduction, usually costing no more than $20. A small amount can make a big difference in the strength of the experience, particularly when it comes to research chemicals that are powder-based.
When it comes to O-acetylpsilocin trips, most people report that they last roughly four to eight hours, with an afterglow that can last up to 48 hours after the experience ends.
Psychonaut Wiki has mapped out the duration as such:
- Total: 4 – 7 hours
- Onset: 15 – 40 minutes
- Come Up: 30 – 75 minutes
- Peak: 2 to 3.5 hours
- Offset: 1 – 2 hours
- After effects: 4 – 48 hours
Also, the trip of 4-AcO is highly dose-dependent. The most common description is that, at low to moderate doses of about 15 to 30 mg, the trip is similar to a crisp, lucid, warm mushroom experience. “4-AcO has a cheerful, lighthearted personality that is almost childlike. Similar to mushrooms, but crispier and more transparent,” wrote Steven*, a survey participant who had taken 10- to 50-milligram doses of 4-AcO hundreds of times. “The trip is a little gentler and simpler than mushrooms, but it still has a similar effect.”
There is a lot of drifting, waving, and breathing in the visuals in this dosage range, which also seems to be comparable to what people experience when taking mushrooms. However, some claim that it’s a little more geometric than mushrooms, shop here.
- DMF: 30 mg/ml
- DMSO: 10 mg/ml
- Ethanol: 20 mg/ml
- PBS (pH 7.2): 10 mg/ml
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The Chemistry of 4-AcO-DMT
Then, the psychedelic mushroom compound psilocybin, also known as the magic mushroom or psilocybin mushroom, has a structural analog in psylacetin.Psilocin is an analogue of the neurotransmitter serotonin, and psilocybin is a prodrug of psilocin. Chemically, psilocybin is O-phosphorylated, while psilacetin is O-acetylated psilocin, shop here.
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The Pharmacology of 4-AcO-DMT
Also, Hofmann and Troxler define indole acetate esters, such as 4-AcO-DMT, as antagonists of serotonin receptors in their 1963 patent. OneBy analogy to psilocybin, scientists have come to categorize them as prodrugs, though, meaning that they are inactive on their own.
Then, It’s unclear how the human body breaks down psilacetin. Still, it makes sense to believe that psilacetin deacetylates to psilocin given the chemistry and metabolism of related tryptamine compounds. Following the widely accepted theory, psilocin would then bind to the serotonin 5-HT2A receptor and produce a psychedelic effect.
- DMF: 30 mg/ml
- DMSO: 10 mg/ml
- Ethanol: 20 mg/ml
- PBS (pH 7.2): 10 mg/ml
Shipping & Storage Information
O-acetylpsilocin Entheogenic, Spiritual or Therapeutic Effects?
Thus, Whether or not a person enters an O-acetylpsilocin trip seeking answers to life’s big questions, many find that the experience has strong entheogenic, spiritual, and therapeutic effects. Ryan*, who has taken 4-AcO three times at doses ranging from 15 to 25 mg, stated, “It brings clarity of thought to analyze personal issues.” “I usually learn something useful from the experience. Also, I would like to be more accepting of my own ideas as well. Also, I seem to remember the lessons.
For example, Joe* said, “It revealed to me that I was neglecting platonic relationships, and urged me to be more mindful about strengthening my relationships.” Others who filled out the survey reported the substance helping them heal from different kinds of trauma. “Along with other substances, 4-AcO-DMT helped me heal from my best friend passing away, trauma from growing up in a controlling and abusive cult, being in an abusive relationship with my first girlfriend, and much more,” revealed Sam*.
Additionally, despite the enormous benefits of these spiritual and therapeutic effects, one user note that their strength should be used with respect and caution. I was freed from years of suicidal thoughts by this medication. healed my depression. gave me deep mystical understanding of the afterlife,” Matt remarked. “[But] because of its potency, I’ve occasionally learned things from it that I didn’t want to learn, and because of the drug’s existential significance, I hardly ever take it now.”
Also,4-AcO-DMT tolerance increases almost instantly after consumption and takes a week or so to leave your system and return to normal. This tolerance extends to other traditional psychedelics as well, so the effects of taking psilocybin mushrooms or LSD within a week may be significantly milder than usual.
Then, It’s also critical to remember that 4-AcO has a low potential for abuse because it is not thought to be addictive. However, this does not preclude the possibility of an unhealthy relationship with the substance, so when using it, always practice mindfulness, intention, and self-honesty.
Is 4-acetoxy-DMT Legal?
Also, In many countries, 4-acetoxy-DMT’s legal status is somewhat ambiguous and in the legal gray area. This is due to the fact that 4-AcO is not listed in any international drug schedules, such as the United Nations Convention on Psychotropic Substances. Although 4-AcO is not scheduled in the US, if you are found in possession of the off-white powder, you may still face charges under the Federal Analogue Act, a part of the Controlled Substances Act that permits the prosecution of any compound that is “substantially similar” to a Schedule I or II substance if it is intended for human consumption. Consequently, the production, distribution, or possession of psilacetin may be illegal due to its analogue, psilocin, which is classified as a Schedule I drug.
Also, In Canada there is no legislation for or against 4-AcO, and so it’s pretty easy to buy the substance online. A handful of countries have also decriminalized 4-AcO-DMT for small personal use possession, but that still doesn’t make it legal; it can still be confiscate and you can still be fined, while more serious actions like deportation have been report, as well.
List of countries that have banned 4-AcO in some way:
- New Zealand
- United Kingdom
- United States
Is it Safe to Mix Synthetic Shrooms with Other Substances?
Furthermore, 4-AcO sometimes known as “synthetic mushrooms,” is often mixed with cannabis and other psychedelics; however, poly-drug mixes can still be erratic, potent, and carry additional risk. Therefore, before combining it with other entheogens, it’s best to familiarize yourself with the substance on its own, just like you would with any other psychedelic.
Also, the most popular combination seems to be cannabis plus 4-AcO-DMT. As with other cannabis-based psychedelic combinations, the main effect is an intensification of the experience, with the visual and cognitive effects of the 4-AcO being particularly prominent. Also, Cindy mentioned in our survey that she felt more confuse and anxious after this interaction, which is cautioned against by Psychonaut Wiki. “I overindulged in marijuana during my worst [4-AcO] trip. For roughly five minutes, it was cool. But afterwards, I felt
Then, the risk of panic attacks and psychosis are also increase when you add cannabis into the mix. Also, If you’re set on experimenting. Also, it’s best to consume much smaller amounts of cannabis than you might normally, and wait at least an hour or more before re-introducing cannabis again in order to avoid over consumption.
Moreover, reports of 4-acetoxy-DMT being combine with ketamine, LSD, and MDMA have been made. These combinations can also produce more vivid, intense experiences, but there’s also a greater potential for disorientation, nausea, and hallucinations. Also, when planning to mix multiple substances, always keep your doses lower and practice other harm reduction techniques like having a sober trip sitter and a prepared set and setting. In the case of MDMA, it has been speculated that 4-AcO could increase the neurotoxic effects of MDMA.
Then, Drugs like lithium, tramadol, and stimulants like Adderall (but also cocaine and meth) are known to interact with 4-AcO. It has been anecdotally demonstrated that combining the two in the case of lithium increases the risk of psychosis and seizures.
Lastly, some folks have been known to mix 4-AcO with benzodiazepines (like Klonopin and Xanax) or alcohol to lessen the psychedelic effects. They can both dull the trip if it’s too intense, but with caution. They should both be taken in very low doses, and in the case of alcohol, could cause increase nausea. With benzos, some memory loss could be possible and so you’ll likely have less ability to process and integrate the trip later on. All in all, always be cautious and mindful of poly-drug mixes and do your homework before mixing multiple substances.