4-AcO-DMT: The Ultimate User Guide

4-AcO-DMT: The Ultimate User Guide

4-aco-dmt blog image

Firstly, People have been interested in psychedelic substances for a long time. While some psychedelic substances are created in laboratories, many are found in nature. The remarkable compound 4-AcO-DMT is one example.

Often called “synthetic mushrooms,” these semi-synthetic psychedelics are well known for having subjective effects akin to those of psilocybin mushrooms. Due to its extensive effects on consciousness, senses, and perceptual experiences, AcO-DMT is highly valued as a psychedelic.

The technical jargon of AcO-DMT is being simplified and condensed into digestible information in this guide. For those who are keen to try the compound but have no prior knowledge, this is a useful guide.

???? Key Takeaways

  • 4-AcO-DMT’s effects are closely related to psychedelics—psilocybin and psilocin.
  • The semi-synthetic compound partially activates the 5-HT2A receptor in the brain to bring about psychedelic effects.
  • AcO-DMT in powder, capsule, and other forms are taken orally or intranasally.
  • The “grounding” compound is highly dose-dependent. A small dosage yields effects similar to psilocybin and higher doses resemble the DMT experience.
  • Several considerations including physical/mental state, legality, proclivity to substance abuse, and more are taken into account before using 4-AcO-DMT.

Overview: What Is 4-AcO-DMT?

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In 1963, Franz Troxler and Albert Hofmann made the first batch of 4-AcO-DMT. However, it wasn’t until David E. Nichols suggested the substance as a potent substitute for psilocybin in 1999 that the effects were thoroughly documented. The popularity of AcO-DMT for recreational purposes peaked in 2010 and has since fluctuated.

Chemically speaking, AcO-DMT, also known as 4-Acetoxy-N,N-dimethyltryptamine, belongs to the same psychedelic tryptamine class as DMT and bufotenin. Its molecular makeup bears similarities to the psilocybin and psilocin found in popular magic mushrooms.

4-AcO-DMT may have an impact on serotonin receptors, which are important for happy emotions in the brain. Its general behavior within the body hasn’t been studied or recorded, though, 4-AcO-DMT is a semi-synthetic compound that comes from a naturally occurring.

Subjective 4-AcO-DMT Effects: What to Expect?

The 4-AcO-DMT effect is vast. It’s categorized into physical, cognitive, visual, auditory, multi-sensory, and transpersonal effects. However, in general, users report AcO-DMT effects to be similar to psilocybin mushrooms—euphoric, relaxing, gentle, warm, and colorful. 

Here’s a chart detailing the effects of 4-AcO-DMT on different aspects:

Category of Effects Potential Effects
Physical Sedation
Bodily sensations
Tactile enhancements
NauseaFluctuations in bodily temperature
Muscle contractions and relaxation
Watery eyes
Frequent urination
Taste enhancement
Sense of smell enhancement
Pupil dilation
Runny nose
Teeth grinding
Brain zaps
Increased salivation
Cognitive  Outrospection
Conceptual thinking
Emotional enhancement
Increased sense of humor
Increased appreciation of art like music or movie
Time distortions
Déjà vu
Increased fascination
Decreased cultural biases
Multiple thought streams
Spontaneous feeling of multiple emotions
The preference to not talk aloud
Waves of profound thinkingIntense feeling of happiness
Emotional insight
Mental clarity
Slowed thoughts
Looping of thoughts
Organizing thoughts
Visual  Clarity of vision
Color enhancement
Tendency to recognize patterns
Distant details appear closer
Changing external objects’ colors
Tinted vision
Cloudy visual distortion of the surrounding environment
Seeing rainbows and spectrums of colors
Visual perceptions that continue to appear
Textures mirrored repeatedly on your vision
Change of an object’s original size
A nearby object that might appear distant to you
Some hallucinations
Auditory (Hearing) Increased clarity of sounds
Perceived changes in sounds
Spontaneous hearing of imaginary voices
Multi-sensory  A person may begin to see sounds, hear smells, etc. (rare even at high doses)
Transpersonal Existential thoughtsDepersonalizationShift in beliefs of existence, religion, and similar concepts

It is noteworthy that the effects of AcO-DMT are not always predictable. In other words, there is no guarantee that anyone will always experience the same set of effects or that any effects will materialize at all.

While lower doses may provide a brief experience of mild psychedelic effects, higher doses produce more extensive 4-AcO-DMT effects and side effects.

How Does 4-AcO-DMT Work?

4-AcO-DMT cannot produce its effects unless it is ingested orally or intranasally. The mechanism of the compound’s oral mechanism of action is better documented than that of the intranasal route. This is how it works, then:

When 4-AcO-DMT enters the digestive tract, it undergoes first-pass liver metabolism, which results in the conversion of psilocin. The product’s concentration and strength have been slightly decreased at this point.

The freshly transformed AcO-DMT now travels to the brain through the bloodstream. It is thought that the substance partially activates the 5-HT2A receptor, which is in charge of triggering psychedelic effects.

What Are the Different Ways of Taking 4-AcO-DMT? 

4-AcO-DMT is consumed in two main ways: Oral ingestion or through the intranasal route. Both methods are dosed differently in microdosing or higher dosing styles for enhanced effect.

Oral Ingestion

The oral ingestion of AcO-DMT is a straightforward way of taking the compound through the mouth. The onset of effects takes about 20-40 minutes and peaks around 2-3 hours. Effects could last as long as 6 hours.

Several oral products are available such as:

  • Premeasured pills: Contains premeasured dosage of AcO-DMT per pill or capsules.
  • Powder: Dissolved in water and other complementing beverages.

Intranasal Route

The intranasal route sometimes called “insufflation” or “snorting AcO-DMT” is inhaling powder to your nose. The effect has a quicker onset and peak but with a shorter duration.

Experienced users are the ones most suitable for the intranasal route of 4-AcO-DMT because of its strong potency.

???? Additional Facts

The less common consumption methods of 4-AcO-DMT include vaporization and intravenous administration (injection). These methods are rarely used because of increased risks and difficulty in dosage control.

What Is the Correct 4-AcO-DMT Dosage?

4-AcO-DMT is a substance that is dose-dependent. This implies that different dosages have different effects. Every user has a different intensity and experience with different dosage levels of 4-AcO-DMT.Lower dosages of the psychedelic generally have an effect akin to that of psilocybin. Higher dosages, meanwhile, are similar to ingesting a DMT (dimethyltryptamine).The dosage of 4-AcO-DMT is 5–45 mg. The more accurate dosage range, which people typically only take, is between 10 and 30 mg. Individuals who are inexperienced or have low tolerance typically take smaller doses. More than 30 mg are taken by those with more experience and who have grown tolerant to the substance.

???? Immersion

Taking 20 mg of 4-AcO-DMT is like consuming 3 grams of dried psilocybin mushrooms.

Here are the dosage ranges for each type of 4-AcO-DMT consumption method:

Oral Ingestion Dosage Range

Level Dosage Range Suitable For
Microdose 2.5 – 5 mg No psychedelic experience
Low Dose 5 – 10 mg 4-AcO-DMT beginners but with experience with psychedelics
Moderate 10 – 20 mg Experienced users
High Dose 20 – 40 mg Experienced users with high tolerance
Heroic 40 – 45 mg Not recommended for anyone

Intranasal Route Dosage Range

Level Dosage Range Suitable For
Microdose less than 5 mg No psychedelic experience
Low Dose 5 – 10 mg 4-AcO-DMT beginners but with experience with psychedelics
Moderate 10 – 20 mg Experienced users
High Dose 20 – 30 mg Experienced users with high tolerance
Heroic 30 mg + Not recommended for anyone

Furthermore, the potency of the 4-AcO-DMT powder varies greatly, and only a tiny amount will significantly alter your experience. As a result, think about making an investment in a milligram-reading scale so you can weigh the product yourself. If you are the only one who can measure dosage, this is a useful practice.

It should be noted that potency varies amongst AcO-DMT products. A 4-AcO-DMT hydrochloride salt, for instance, will have a greater effect than its fumarate salt counterpart. Therefore, the effects of a 25 mg dosage of 4-AcO-DMT fumarate will differ from those of a 25 mg dosage of its hydrochloride salt version, shop here.

???? Golden Rule of Dosing

If you’re new to 4-AcO-DMT or just in general wary about getting a bad trip, start from the lowest dose possible (about 5 mg). Increase gradually until you reach the sweet spot of dosing—you’re getting the desired effects without experiencing any intolerable side effects.

How to Use 4-AcO-DMT for Personal Growth?

While 4-AcO-DMT is known for its psychedelic and hallucinogenic effects, some people use it for triggering introspective conversations, exploring themselves, and growing from the experience. Not all individuals, however, are fit for AcO-DMT use such as:

  • Pregnant people
  • Minors
  • Predisposed to bad trips
  • Those with preexisting mental and physical health conditions
  • Currently on medication
  • Struggling with substance abuse
  • History of prior convictions

Also, If you’re none of those mentioned and you’re committed to trying AcO-DMT, you need to know that psychedelics can impact your mental health profoundly. As for the general guidelines for safely using the substance, here are some rules to keep in mind:

  1. Set a Schedule and Setting

Pick a date when you’re unoccupied for the whole day. Next, make sure the environment where you’re staying throughout the experience is a safe and comfortable space.

Above all, prepare yourself. Make sure you are in a balanced state of mind before taking any psychedelic substance.

  1. List down your intentions for taking AcO-DMT

Identify what your intentions are for taking 4-AcO-DMT. Are you using it for recreational purposes? Are you trying to discover yourself? Defining your purpose will dictate how you would dose 4-AcO-DMT correctly to achieve the desired effects, shop here.

  1. Dose 4-AcO-DMT correctly

There is no universal dosage guideline that says dosage “x” will yield “y” results. Since 4-AcO-DMT effects are subjective for different people, it’s up to you to discover your best dosage.

Using the outlined dosage recommendation for each type of user as the basis, start with the lowest end of the dosage range. If the effects are too weak try adding your dose slightly for your next sessions.

  1. Practice mindfulness and meditation

Try to practice mindfulness and meditation activities during your psychedelic experiences. Some examples include deep breathing, guided meditation, etc. Doing so helps improve your experience, prevent bad trips, open your mind, and more.

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One of the key benefits of meditating before taking psychedelics is it helps bring you to a state of ego dissolution. This state of mind streamlines your consciousness in the moment. You will feel as if you’re not an individual but a fluid being that is one with the universe and its inhabitants.

  1. Document your experience

Then, Write down your feelings, emotions, and thoughts by journaling. Do this during the trip and it will help you process your emotions later and record cool thoughts during the session.

  1. Consider the legal and health impacts of 4-AcO-DMT

Research the legal standing of 4-AcO-DMT in your state or area before indulging. Also, reconsider trying the substance if you’re not entirely sure it will bring a positive contribution to your physical and mental well-being.

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Relieve stress and anxiety spikes naturally by exercising, mindful breathing, meditating, avoiding anxiety-inducing food, getting proper sleep, and more to prepare you for the profound effects of 4-AcO-DMT.

  1. Talk to mental health professionals or experts in the field

Consider consulting with a mental health professional and other people educated in the psychedelic-assisted field for guidance. Trying 4-AcO-DMT for personal growth or any purpose is a complex and highly subjective matter.

What Are the Differences Between AcO-DMT and Other Psychedelics?

4-AcO-DMT vs. Psilocybin Mushrooms

Psilocybin mushrooms are deemed the closest to 4-AcO-DMT regarding similarities in effects and molecular structure. 4-AcO-DMT is even dubbed as the semi-synthetic version of shrooms, shop here.

Also, 4-AcO-DMT and psilocybin mushrooms share the same active ingredient once metabolized in the body—psilocin. If you can remember, psilocin partially activates the brain’s 5-HT2A receptors to activate psychedelic effects.

Despite the similarities between 4-AcO-DMT and psilocybin mushrooms, there are subtle differences between the two such as the following:

  • Low doses of 4-AcO-DMT produce more mellow effects than magic mushrooms. If 4-AcO-DMT effects are calmer and more introspective, psilocybin mushrooms’ effects tend to be fuzzier.
  • The onset of 4-AcO-DMT effects is far quicker than psilocybins which can take about 20-40 minutes through oral ingestion.
  • There is less chance of getting nauseated with 4-AcO-DMT. On the other hand, nausea is one of the common side effects of magic mushrooms as they contain chitin or fiber materials that can irritate the stomach.
  • Higher doses of 4-AcO-DMT produce a more profound psychedelic effect than higher doses of psilocybin mushrooms.

4-AcO-DMT vs. 5-MeO-DMT

4-AcO-DMT and 5-MeO-DMT look similar in terms of molecular structure. Both compounds also activate the 5-HT2A receptors but their main difference from each other lies in potency.

  • Compared to 4-AcO-DMT, 5-MeO-DMT’s psychedelic experience is on another level. Users report an out-of-body experience rarely induced by available psychedelics. The effects are profoundly deeper compared to 4-AcO-DMT.
  • 5-MeO-DMT’s effects last quicker by about 30 minutes while 4-AcO-DMT’s effect can stretch up to 6 hours (depending on dosage).

4-AcO-DMT vs. LSD

LSD acid (Lysergic Acid Diethylamide) and 4-AcO-DMT target the same brain receptors but with varying binding affinity. The differences in their binding strengths are the cause for their unique chemical traits.

LSD gives a more clear-headed and visual psychedelic experience than 4-AcO-DMT. Meanwhile, 4-AcO-DMT’s effects lean toward the “more grounding” side.

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What is the 4-AcO-DMT Legality in the US?

It is unclear what 4-AcO-DMT’s legal status is at the federal and even state levels. 4-AcO-DMT is exempt from US federal legal scrutiny since it is not listed as a controlled substance by the Drug Enforcement Administration (DEA). Additionally, 4-AcO-DMT is an agent that is freely used in labs for research.

???? Definition of “Controlled Substances”

Controlled substances are drugs or chemical substances whose “manufacture, possession, or use,” is regulated but the government. Examples of these are illicitly used drugs or prescriptions designated by law. Refer to this link to get an updated list of DEA’s controlled substances.

Then, the sole drawback is that 4-AcO-DMT is regarded as a psilacetin analogue, similar to psilocin. The substance is metabolized within the body to become psilocin. A Schedule I drug under the Controlled Substances Act is psilocin.

Then, according to the Federal Analogue Act, there are legal repercussions for any substance that is intentionally consumed by humans for non-medical or research purposes and that is strikingly similar to any Schedule I drug.

Civilian prosecutions for possession of 4-AcO-DMT are “virtually nonexistent.” This does not, however, imply that there is no possibility of prosecution under the Federal Analog Act.

It will be interesting to watch how companies that sell 4-AcO-DMT products or brands that deal with mushrooms handle the complicated legal landscape surrounding psychedelics.

Where to Buy 4-AcO-DMT Online?

In addition, It appears that most countries, including the US, are having trouble finding 4-AcO-DMT these days. Still, in certain regions of Europe and Canada, 4-AcO-DMT products are still available in a clean and safe manner. Vendors of research chemicals in those nations offer them for reasonable prices; a 25 mg dosage costs roughly CA$6.25.

You may run into some issues when importing 4-AcO-DMT into the United States. It’s not impossible to run afoul of the Transportation Security Administration (TSA) or U.S. Customs and Border Protection.

Additionally, watch out for con artists who sell 4-AcO-DMT for extremely low prices. The limited availability of 4-AcO-DMT may be exploited by social media and dank web vendor, shop here.

The Future of AcO-DMT

Furthermore, Unbeknownst to the public for years, 4-AcO-DMT is one of the most potent psychedelics. Companies are patiently developing compliant 4-AcO-DMT products as a result of the gradual but undeniable interest in psychedelics.

Until then, people who enjoy psychedelics will need to locate edible cannabis products that are just as amazing and may even have psychedelic effects. And with 13 years of experience creating high-quality hemp products, The Hemp Doctor is the best resource for that information.

Also, we have feel-good and noticeable effects in each of our gummy options, which include Delta 8, Delta 9, THCA, HHC, and CBD. Don’t worry, there is something to suit every taste.


Can you buy 4-AcO-DMT from Etsy?

You can buy psychedelics on Etsy Canada in general. However, you won’t see many 4-AcO-DMT vendors in the e-commerce platform. A bunch of related psychedelics like mushrooms and plants will emerge instead.

How to synthesize 4-AcO-DMT?

It’s possible to synthesize 4-AcO-DMT but there will be several factors to look at like your expertise on the matter, the legal hurdles you need to overcome, and the complication of synthesizing (not extracting). Here’s a paper detailing how chemists were able to create the compound from scratch, shop here.

What should be the color of a AcO-DMT powder?

4-AcO-DMT comes in hydrochloride and fumarate salts. Each has its distinct colors and characteristics. The hydrochloride version is whitish brown while the 4-AcO-DMT fumarate salts have a darker whitish brown hue.

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